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Abstracto

Clinical Evaluation of Gestational and Congenital Toxoplasmosis in Two Health Institutions in the City of Monteria, Colombia from 2015 To 2021

Kelly Johana Madera Arteaga*, Eduardo Luis Rivera Alarcon, Jiseth Paola Avilez Aleman, Angelica Maria De Los Reyes Aldana, Sandra milena negrete Contreras, Rafael Chica Polo, Marcia Rosa Espitia Yabrudy, Oriana Liz Pineda Espitia8, Carlos Mauricio Vergara lobo

Introduction: Toxoplasmosis is a zoonotic disease widely distributed throughout the world, caused by T. gondii, which infects various tissues and organs. Infection during or just before pregnancy can cause congenital toxoplasmosis and cause serious damage, especially at the CNS level. Objective: To evaluate the clinical characteristics of toxoplasmosis in pregnant women and new-borns in two health institutions in the city of Montería.

Methodology: a retrospective study was carried out in 2 health institutions in the city of Montería, between January 2015 and May 2021, in new-borns of a mother with a diagnosis of gestational toxoplasmosis. Results: 76 clinical histories of neonates, children of mothers with Introduction: Toxoplasmosis is a zoonotic disease widely distributed throughout the world, caused by T. gondii, which infects various tissues and organs. Infection during or just before pregnancy can cause congenital toxoplasmosis and cause serious damage, especially at the CNS level.

Objective: To evaluate the clinical characteristics of toxoplasmosis in pregnant women and new-borns in two health institutions in the city of Montería. Methodology: a retrospective study was carried out in 2 health institutions in the city of Montería, between January 2015 and May 2021, in new-borns of a mother with a diagnosis of gestational toxoplasmosis.

Results: 76 clinical histories of neonates, children of mothers with gestational toxoplasmosis, diagnosed by IgM were analyzed. 50% of the pregnant women were treated and congenital toxoplasmosis was confirmed in 8 neonates: 5 with positive IgG and IgM, 2 with positive IgG and indeterminate IgM, with negative IgA and one with negative IgG and IgM symptoms. The clinical findings were hepatosplenomegaly and jaundice; eye disorders; ventriculomegaly and intraparenchymal calcifications in the brain and dilation of the left heart chamber. 62.5% of neonates with a clinical and/or serological diagnosis were treated with pyrimethamine / sulfadiazine plus folinic acid or pyrimethamine / sulfadoxine.

Conclusions: The diagnosis of gestational and congenital toxoplasmosis was made mainly by serology. Most of the pregnant women received treatment; however, there is still inefficiency in it. More than 60% of neonates with congenital toxoplasmosis received treatment at discharge; even so, there should be no limitations to access it.