Archivos en Investigación del Cáncer

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Abstracto

Using CRISPR/Cas9 as precise and high-throughput genetic engineering tools in the study and treatment of gastrointestinal cancer

Tasmim Bintae

Cancer accounted for pretty much 10 million deaths worldwide in 2020. Metastasis, characterised by neoplastic cell invasion to alternative components of the body, is that the main reason for cancer morbidity and mortality. Therefore, understanding the molecular mechanisms of tumour formation and discovery of potential drug targets square measure of nice importance factor written material techniques are often accustomed realize novel drug targets and study molecular mechanisms. During this review, we have a tendency to describe however common gene-editing ways like CRISPR/Cas9, TALEN and ZFNs work, and, by comparison them, we have a tendency to demonstrate that CRISPR/Cas9 has superior potency and exactness. we have a tendency to more give an outline of the recent applications of CRISPR/ Cas9 to cancer analysis, that specialize in the foremost common cancers like carcinoma, carcinoma, body part cancer, and prostatic adenocarcinoma. we have a tendency to describe however these applications can form future analysis and treatment of cancer, and propose new ways in which to beat current challenges.

Thyroid cancer; Sarcoma cells of origin; Sarcoma stem cells; Epidemiology; Cell tumour; Radiation therapy