Towards the Synthesis and Genetically Screening of a Halisarca ectofibrosa

The first solution-phase synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) was accomplished by coupling dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. The deportation of the linear tetrapeptide unit and subsequent cyclization produced a cyclopeptide that was identical in every way to the naturally occurring compound. The bioactivity results showed that the synthesised peptide had antifungal and antihelmintic properties against pathogenic dermatophytes and earthworms.

Keywords

Natural product synthesis; Marine bacteria; cyclic tetra peptide; Biological activity

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Enzimología molecular y dianas farmacológicas

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Abstracto

Towards the Synthesis and Genetically Screening of a Halisarca ectofibrosa