Matthew Brown
Background and goal to offer a scoping overview of studies that have been published employing small animal irradiators and to draw attention to the advancements made possible by these platforms in preclinical radiation research since their creation and commercialization in 2007. Materials and procedures 359 small animal RT trials were included in the analysis after 907 studies were found by screening using manufacturer data and PubMed searches. To detect trends in the preclinical RT research landscape, these publications were divided into subgroups based on research objectives, experimental models, and other criteria and classed as contributions from the fields of biology or physics. Results Between 2007 and 2021, biology contributions made up the majority of articles that were published, while physics contributions made up 38% of publications. In physics papers, dosimetry and calibration treatment were the primary study fields. The developments in small animal irradiator-based preclinical RT research are covered in this study from 2007 to 2021. Our findings indicate a rise in the number of preclinical RT investigations being conducted in crucial fields of biology and physics research that might help guide the translation of those findings into clinical trials.
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