Mark Roy
Social anxiety disorder (SAD) is the fourth most prevalent psychiatric disorder after Major Depressive Disorder, Specific Phobias, and Alcohol Use Disorder. It affects 1.6–12.1% of people globally at some point in their lives. Individuals with this illness have a strong dread of and avoidance of social contacts and circumstances, resulting in considerable impairment in many parts of their lives. Only about 30% of those treated make a complete recovery from SAD symptoms, necessitating the development of new treatments. Although the illness processes in SAD are unknown, anatomical regions involved in 'fear neurocircuitry' have been linked to the disorder. The thalamocortical, corticocortical, and corticostriatal circuits are the main components of fear neuro circuitry. Glutamate (Glu) neurotransmission is regulated by multiple feed forward, feedback inhibition, and disinhibition mechanisms involving many GABA ergic inhibitory neurons.
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